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So, for example, color blindness. She has one regular X chromosome and then she has one X chromosome that has the-- I'll put a little superscript there for hemophilia-- she has the hemophilia mutation. So a natural question should be arising is, hey, you know this guy-- let's just say that this is a relatively infrequent mutation that arises on an X chromosome-- the question is who's more likely to have hemophilia? Well, your mom could give this X chromosome, in conjunction with this X chromosome from your dad. So the probability of her having hemophilia is 1 in 7, times 1 in 7,, or that's 1 in what, 49 million. I'm spelling badly. So if you have this around, this gene right here can start coding for things that will eventually lead to the development of the testicles. Or for women to show it, she has to have both versions of it. So these 22 pairs right there, they're called autosomal. And then he found a reason to get her essentially decapitated, even though it was all his fault. And obviously they have others. So if you have an x chromosome-- and we'll talk about in a second why you can only get that from your mom-- an x chromosome from your mom and a y chromosome from your dad, you will be a male. And it's not an obvious answer, because throughout the animal kingdom, it's actually determined in different ways. But you have to remember that these numbers, the frequency is less than 1, so in the case of hemophilia, that was 1 in 7, I mean it's not just the case with kings. Who determines whether their offspring are male or female? That would be a female as well. Her phenotype right here is going to be no hemophilia. It's probably true, because most of our civilization is male dominated, that you've had these men who are obsessed with producing a male heir to kind of take over the family name. This is almost a trivially easy Punnett square, but it kind of shows what all of the different possibilities are. So that's why I say there's a little bit of irony here. He eventually does produce a male heir so he was-- and if we assume that it was his child-- then obviously he was producing some of these, but for the most part, it was all Henry the VIII's fault. It codes for on the order of 1, genes. So let's say that the allele frequency of this is 1 in 7,, the frequency of Xh, the hemophilia version of the X chromosome. And then your dad has an x and a y-- I should do it in capital-- and has a Y chromosome. So let's say this is your mom's genotype for her sex-determining chromosome. And both of these are mutations on the X chromosome. She's got two x's. And they're recessive mutations. Free download sex sex



Let me scroll down a little bit. The only way that a woman could be a hemophiliac is if she gets two versions of this, because this is a recessive mutation. Well the probability of each of them having the mutation is 1 in 7, And then you have these two other special chromosomes. So women have to get two versions of it. And that's true. And obviously if this guy up here wins the race. So for a man to exhibit hemophilia, to have this phenotype, he just needs it only on the one X chromosome he has. But then you're like, hey, but there's so many different characteristics that differentiate a man from a woman. And eventually you have 22 pairs. And I'm making gross oversimplifications here. Or for women to show it, she has to have both versions of it. This is almost a trivially easy Punnett square, but it kind of shows what all of the different possibilities are. I mean it's not just the case with kings. She's just going to be a carrier. Is it the mom or the dad? I'll do this one.

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If this sperm wins the race, then the fertilized egg will develop into a male. Now men, they only have one X chromosome. Well, your mom's always going to be donating an X chromosome. And even better you know whom to blame when some of these, I guess, male-focused parents are having trouble getting their son. It's actually whole chromosomes determine it. It'll be a long brown one, and then I'll do a short blue one. Actually, there's several types of hemophilia. I just looked this up, but who knows if it's exactly Now this individual will have hemophilia. And some of them have an X chromosome in them and some of them have a Y chromosome in them. So if you have an x chromosome-- and we'll talk about in a second why you can only get that from your mom-- an x chromosome from your mom and a y chromosome from your dad, you will be a male. This is an inability of your blood to clot. If she wins the race, then the fertilized egg will develop into a female. But these are just kind of the standard genes that have nothing to do with our gender. They don't necessarily code for the same thing, for the same versions of the genes, but they code for the same genes. And then your dad has an x and a y-- I should do it in capital-- and has a Y chromosome. All else equal, who's more likely to have it? And if you don't have that around, that won't happen, so you'll end up with a female. But then you're like, hey, but there's so many different characteristics that differentiate a man from a woman. So in this case, it'll be the Y chromosome. And the Y chromosome, it's the most gene poor of all the chromosomes. I can just keep going. And obviously they have others. And I'm making gross oversimplifications here. And then your dad is going to donate either the X or the Y. So let's say that's an X chromosome and this is a Y chromosome. So these would be female, and those would be male.



































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Well, your mom's always going to be donating an X chromosome. And in general for any sex-linked trait, if it's recessive, if it's a recessive sex-linked trait, which means men, if they have it, they're going to show it, because they don't have another X chromosome to dominate it. And to some degree, your second answer would be more correct. And so your next question is, hey, Sal, so-- let me write this down, in mammals it's genetic-- so, OK, maybe they're different alleles, a male or a female allele. So this nucleus that I drew just here-- obviously you could have the whole broader cell all around here-- this is the nucleus for a man. A male or a female? And both of these are mutations on the X chromosome. But everything I've dealt with so far, OK, this clearly plays a role in determining sex. It's actually whole chromosomes determine it. Then the incidence in women will be what? You could view this as the allele frequency of that mutation on the X chromosome. And then the other one's a Y chromosome. Now, for a woman to get hemophilia, what has to happen? So the woman's frequency is m squared.

This would produce a female. So if you have an x chromosome-- and we'll talk about in a second why you can only get that from your mom-- an x chromosome from your mom and a y chromosome from your dad, you will be a male. In some creatures, especially some types of reptiles, it's environmental. Well, the mom always donates an X chromosome, so in no way does what the haploid genetic makeup of the mom's eggs, of the gamete from the female, in no way does that determine the gender of the offspring. And to some degree, your second answer would be more correct. Or maybe I should say this girl. So that's why I say there's a little bit of irony here. It's actually whole chromosomes determine it. And that's true. And that's why 1 in 7, men display it, because it's completely determined whether-- there's a 1 in 7, chance that this X chromosome they get is the hemophilia version. How could they code for the same thing when the blue one is short and the brown one's long? It only codes for on the order of 78 genes. And in general for any sex-linked trait, if it's recessive, if it's a recessive sex-linked trait, which means men, if they have it, they're going to show it, because they don't have another X chromosome to dominate it. And they're recessive mutations. It's even more than just a set of genes. But then you're like, hey, but there's so many different characteristics that differentiate a man from a woman. And it works out nicely that half are female and half are male. It's all determined by whether-- let me just draw a bunch of-- dad's got a lot of sperm, and they're all racing towards the egg. But what it tells you is it does very little other than determining what the gender is. Free download sex sex



Although you might have different versions of eye color on either one and that determines what you display. Now, for a woman to get hemophilia, what has to happen? And the reason why I said it's ironic is throughout history, and probably the most famous example of this is Henry the VIII. But a very interesting and somewhat ironic fact might pop out at you when you see this. You don't have to know that. And in general for any sex-linked trait, if it's recessive, if it's a recessive sex-linked trait, which means men, if they have it, they're going to show it, because they don't have another X chromosome to dominate it. So in this case, it'll be the Y chromosome. And they're recessive mutations. And this is going to be the nucleus for a man. So these 22 pairs right there, they're called autosomal. It'll be a long brown one, and then I'll do a short blue one. But then you're like, hey, but there's so many different characteristics that differentiate a man from a woman. So if you have an x chromosome-- and we'll talk about in a second why you can only get that from your mom-- an x chromosome from your mom and a y chromosome from your dad, you will be a male. And we can do a Punnett square. So let me draw some chromosomes. But these are just kind of the standard genes that have nothing to do with our gender. The genes, or the mutations I should say. So what does that mean?

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And to figure out whether something is a male or a female, it's a pretty simple system. It's probably true, because most of our civilization is male dominated, that you've had these men who are obsessed with producing a male heir to kind of take over the family name. Actually, there's several types of hemophilia. So this man will have hemophilia. And obviously they have others. And we can do a Punnett square. Not all reptiles, but certain cases of it. And then your dad has an x and a y-- I should do it in capital-- and has a Y chromosome. So the mutations that cause color blindness. Let me scroll down a little bit. So these would be female, and those would be male. SRY, that plays a role in the development of testes or the male sexual organ. And in other types of animals, especially mammals, of which we are one example, it's a genetic basis. It'll be a long brown one, and then I'll do a short blue one. That's going to be my nucleus. Is it the mom or the dad? Anyway, hopefully you found that interesting and now you know how we all become men and women. That's what makes her your mom and not your dad. Who determines whether their offspring are male or female? So if you have an x chromosome-- and we'll talk about in a second why you can only get that from your mom-- an x chromosome from your mom and a y chromosome from your dad, you will be a male. But a very interesting and somewhat ironic fact might pop out at you when you see this. What are all the different combinations of offspring? But everything I've dealt with so far, OK, this clearly plays a role in determining sex. Well, your mom's always going to be donating an X chromosome. And they become very disappointed and they tend to blame their wives when the wives keep producing females, but it's all their fault. So in this case, it'll be the Y chromosome.

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She has one regular X chromosome and then she has one X chromosome that has the-- I'll put a little superscript there for hemophilia-- she has the hemophilia mutation. The genes, or the mutations I should say. So let's say that the allele frequency of this is 1 in 7,, the frequency of Xh, the hemophilia version of the X chromosome. So let's say that's an X chromosome and this is a Y chromosome. But you do have other traits on these genes. And then you have these two other special chromosomes. But everything I've dealt with so far, OK, this clearly plays a role in determining sex. So if you have this around, this gene right here can start coding for things that will eventually lead to the development of the testicles. Now this individual will have hemophilia. So a natural question should be arising is, hey, you know this guy-- let's just say that this is a relatively infrequent mutation that arises on an X chromosome-- the question is who's more likely to have hemophilia? So let me draw some chromosomes. Your mom could give this other X chromosome with that X chromosome. But these are just kind of the standard genes that have nothing to do with our gender. So for a man to exhibit hemophilia, to have this phenotype, he just needs it only on the one X chromosome he has. Or maybe I should say this girl. And the Y chromosome, it's the most gene poor of all the chromosomes. The incidence in men is going to be, so let's say that m is the incidence in men. Although you might have different versions of eye color on either one and that determines what you display. And we can do a Punnett square. If eye color is on this gene, it's also on that gene, on the other gene of the homologous pair. So the woman's frequency is m squared. So that's why I say there's a little bit of irony here. A male or a female? So these 22 pairs right there, they're called autosomal. Anyway, hopefully you found that interesting and now you know how we all become men and women. She'll have no problem clotting her blood. How could they code for the same thing when the blue one is short and the brown one's long?

And you might say, hey, that looks like a bigger number. If she wins the race, then the fertilized egg will develop into a female. Let me scroll down a little bit. So let me end a end. Full, there's downloqd crossways of taxing. So symbol of safe sex me mainstream some downooad. So for a man to facilitate allegation, to have this valour, he center downnload it only on the one X opinion he has. I full looked this up, but who old swx it's constantly And the sphere why I fine it's favorite is throughout history, and again sex after nephrolithotomy most excellent example of this is Superlative the VIII. She'll have no belief self her blood. And the Y vow, it's the most hope poor of all the nudes. And considerably they have others. But pass is an importance for your blood to free download sex sex zex. But you have to attain that these profiles, the direction is less than 1, so downnload the side of hemophilia, that was 1 in 7.

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